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Pittsburgh head coach Mike Tomlin moved to 1-0 against the 49ers for his career with that 2007 outcome, while Harbaugh will be facing both the Steelers and Tomlin for the first time in his present position.
WHEN THE STEELERS HAVE THE BALL
Another reason why the Steelers may not want to go run-heavy is the strength of San Francisco's sturdy defense in that department. The 49ers have limited the opposition to a league-lows of 70.5 rushing yards per game and 3.2 yards per carry and have yet to give up a touchdown on the ground this season, while the team's string of 35 consecutive contests without permitting an individual 100- yard rusher is the third-longest in the NFL since 2000. The unit may not have its best stopper on Monday, though, with All-Pro inside linebacker Patrick Willis (93 tackles, 2 sacks, 1 INT) highly questionable with a hamstring strain that kept him out of last week's loss as well. The Niners were still able to hold Arizona to a mere 55 rushing yards on 23 totes with him out, with emerging star linebacker NaVorro Bowman (113 tackles) and rugged lineman Justin Smith (47 tackles, 6.5 sacks) leading the charge. Skelton came up with 282 passing yards and three touchdowns off the bench, however, with two of those scoring deliveries from 46 yards out or more. The secondary does contain two members with five interceptions each this year in cornerback Carlos Rogers (35 tackles, 15 PD) and free safety Dashon Goldson (54 tackles), while impressive rookie Aldon Smith (27 tackles, 10.5 sacks) and Ahmad Brooks (39 tackles, 6 sacks) offer two quality edge rushers from the outside linebacker positions.
San Francisco generally employs a conservative, ball-control philosophy that's been highly effective when workhorse running back Frank Gore (1054 rushing yards, 6 TD, 16 receptions) is at his best. That was certainly the case when the hard-nosed veteran ripped off five consecutive 100-yard games during a midseason tear, but he's been less of a factor down the stretch while fighting through some nagging injuries. The 49ers still sit seventh in the NFL in rushing offense (126.9 ypg) and have a league-low 10 giveaways on the year, with cerebral quarterback Alex Smith (2565 passing yards, 15 TD, 5 INT) having a fine season in what's been essentially a caretaker's role. There are some issues to sort out for the playoffs, though. San Francisco is at the bottom of the standings in red-zone execution, having produced touchdowns on an unwanted 35.6 percent of such drives, and Smith has been sacked 18 times over the past three weeks after being taken to the turf on five occasions by the Cardinals. The former No. 1 overall pick may be without his blind-side protector on Monday as well, with left tackle Joe Staley questionable after sustaining a concussion against Arizona. San Francisco doesn't throw the ball a whole lot, but young wide receiver Michael Crabtree (55 receptions, 2 TD) and athletic tight end Vernon Davis (49 receptions, 5 TD) have both been reliable targets for Smith.
KEYS TO THE GAME
The 49ers will likely encounter some difficulty running the ball on Monday, especially with Gore not having been in top form lately, so it's absolutely critical that the team protects Smith sufficiently. San Francisco's quarterback has been sacked five or more times in four games this season, and the Niners are 1-3 in those tilts. If Woodley does indeed make it back, Pittsburgh will have a pass rush to be reckoned with regardless of Harrison's absence.
OVERALL ANALYSIS
Sportsbook Betting Lines Predicted Outcome: Steelers 20, 49ers 16
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